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2 months ago
A patient with a diagnosis of active TB has begun second-line therapy that includes the use of pyrazinamide. When monitoring this patient, the nurse should suspect that adverse effects of this drug may account for which of the following laboratory values?
A)Low hematocrit and mean corpuscular volume (MCV)
B)Increased INR and aPTT
C)Increased blood urea nitrogen and creatinine
D)Increased AST, ALT, and GGT
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Abrams' Clinical Drug Therapy: Rationales for Nursing Practice
Edition: 10th
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2 months ago
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The most severe adverse effect of pyrazinamide is hepatotoxicity. Consequently, liver enzymes such as GGT, ALT, and AST should be monitored. Changes in erythrocytes, coagulation, and renal function are less likely to result from pyrazinamide therapy.

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