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A gerontological nurse is aware that increased aldosterone is a major factor in the pathophysiology of heart failure. Which of the following medications reduces aldosterone-induced retention of sodium and water?
A)Hydrochlorothiazide
B)Enalapril maleate
C)Spironolactone
D)Losartan potassium
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Abrams' Clinical Drug Therapy: Rationales for Nursing Practice
Edition: 10th
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Spironolactone (Aldactone) is an aldosterone antagonist that reduces aldosterone-induced retention of sodium and water and impaired vascular function. Thiazide diuretics, ACE inhibitors, and angiotensin IIreceptor blockers do not have this mechanism of action.

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