Homeostatic Imbalances of Thyroid Function:
I am presented with 3 patients:
The normal range for serum TSH is 0.35-4.5 mlU/L. For each patient, type in her serum TSH concentration and indicate if it is lower, within, or higher than the normal range.
Patient 1 with primary hypothyroidism:
TSH level is 12.24 which is higher than the normal range.
Patient 2 with secondary hypothyroidism:
TSH level is 0.07 which is lower than the normal range.
Patient 3 with hyperthyroidism:
TSH level is 0.07 which is lower than the normal range.
For each patient, state whether her thyroid image indicates whether their iodine uptake is low, normal, or high.
Patient 1 with primary hypothyroidism:
Thyroid image shows low iodine.
Patient 2 with secondary hypothyroidism:
Thyroid image shows low iodine.
Patient 3 with hyperthyroidism:
Thyroid image shows high iodine.
Discussion - this is where I need help, please !
For each subject, indicate whether her TRH levels would be low, normal, or high. Please explain your decision. Discuss negative feedback control in your answer.
Subject with primary hypothyroidism:
TRH would be...?
Subject with secondary hypothyroidism:
Subject with hyperthyroidism:
For each subject, explain why iodine uptake would be greater or less than normal.
Subject with primary hypothyroidism:
Subject with secondary hypothyroidism:
Subject with hyperthyroidism:
State how hypothyroidism affects each of the following and describe the mechanism by which this change occurs.
body temperature:
heart rate:
State how hyperthyroidism affects each of the following and describe the mechanism by which this change occurs.
body temperature:
heart rate:
Application:
The subject who was diagnosed with primary hypothyroidism was given levothyroxine (synthetic T4). After 2 months of treatment, her TSH values decreased by 96.38 % and her T4 levels increased by 879.4 %. Explain why her TSH levels decreased and T4 increased?
The subject who was diagnosed with secondary hypothyroidism was given levothyroxine (synthetic T4). After 6 weeks of treatment, her TSH values did not change and her T4 levels increased by 778.62 %. Explain the why TSH did not change and why T4 increased.
The subject who was diagnosed with hyperthyroidism was given propylthiouracil (prevents T4 production and conversion of T4 to T3 in the tissues). After 2 months of treatment, her TSH levels increased by 371.15 % and her T4 levels decreased by 42.7 %. Explain why her TSH levels increased and her T4 levels decreased?
Quick Reply
