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How does a Philadelphia chromosome occur, and what condition does it cause?

barry

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12 years ago

How does a Philadelphia chromosome occur, and what condition does it cause?

How does a Philadelphia chromosome occur, and what condition does it cause?

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duddy

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12 years ago

Ninety percent of patients with the fatal cancer chronic myelogenous leukemia (CML cancer) have a chromosomal mutation in their myeloblasts caused by a reciprocal translocation event between chromosome 22 and chromosome 9. The defective chromosome 22 is called the Philadelphia chromosome.

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