Study found that the new hormone can stimulate insulin secretion

Duke(Duke)University Medical Center researchers found a similar PDE1A insulin-like hormone,the hormone by the pancreas islet cells,has a protective effect,as well as the function of anti-diabetic.The researchers found that this new hormone will stimulate mouse and human islet cells secrete insulin,and can protect islet cells from the toxicity factors used in the study,the damage of the PDE1B cell killing factor.Part of this study is the support of JDRF(type 1 diabetes research worldwide leader),the study published in the July 3"cell metabolism"magazine(the journal Cell Metabolism).The findings on the health and survival of?-cells with new insights,?cell is a type of islet cells produce Pde1c insulin to regulate blood sugar.The discovery opens a new research ideas for the prevention and treatment of type 1 and type 2 diabetes in the future.The researchers will be a hormone called TLQP-21 to give the Zucker diabetic fat rat is a susceptibility to type 2 diabetes genetic predisposition of mice.They found that mice given hormone treatment PDE2A insulin and glucose(sugar)levels significantly increased,and reduced the number of?cell death.The study's senior author,Sarah W.Stedman,Nutrition and Metabolic Center Director Christopher B.Newgard,Dr.(Ph.D.)and Sarah W.Stedman Distinguished Professor W.David said:"We think this discovery is very important,because it demonstrated for the first time the TLQP-21 not only can prevent?-cell deterioration,and stimulate PDE3A insulin secretion in the presence of glucose under the conditions,because when the number of beta cells continuously decreased and insulin produce decline appears diabetes,so looking for the best way to produce this hormone has a protective effect may be of value."

Although the researchers only tested TLQP-21 hormones in type 2 diabetes model,but they plan to increase the test in future studies to test the role of the hormone in type 1 diabetes.Two types of diabetes(type 1 and type 2 diabetes)are pancreatic?cell dysfunction is characterized by.Type 1 diabetes is an autoimmune disease,selective,progressive loss of insulin-producing beta cell function,characterized by this type of diabetes would be more serious.Type 2 diabetes?-cell dysfunction is characterized by peripheral insulin resistance.Most patients with type 2 diabetes eventually will progress to insulin-dependent diabetes.JDRF?cell regeneration project director Dr.Patricia Kilian(Ph.D.),said:"These exciting results provide us with new insights and allows us to further understand the body and how the regulation of?-cells to health and to be survive.We also look forward to the future further research to figure out this new type of hormone is how the impact of?-cell function in type 1 diabetes."TLQP-21 produced within the digestive tract,a natural hormone-glucagon-like peptide 1(GLP-1)relative to certain features similar.Although both play a role in the mechanism is different,but the two hormones can protect and promote insulin secretion.GLP-1 or GLP-1 stable drugs are widely used in the treatment of type 2 diabetes,but there will be some side effects,including increased heart rate and diminished gastric emptying;and its impact on intestinal function has led some people had to be suspended treatment.The next step is to identify a small molecule,such small molecules can stimulate islet cells to produce more TLQP-21 hormone,or to develop more effective and stable form of hormone injection.Newgard,professor of pharmacology and cancer biology,said:moving in the direction of the effect of a longer drug research will ultimately help speed up the trial of the hormone in type 1 diabetes research.