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datasian datasian
wrote...
13 years ago
In the operon model, an inducer and a corepressor are similar in that they each interact with a specific repressor protein. How is this interaction different in enzyme induction compared with enzyme repression?
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wrote...
13 years ago
Enzyme repression -eg the tryptophan operon -
The active repressor/co-repressor complex acts by binding to a specific region of the DNA called the operator which is adjacent to the structural genes being regulated. The structural genes together with the operator region and the promoter is called an OPERON. Thus, in the presence of the co-repressor the repressor is active and binds to the operator, resulting in repression of transcription of the structural genes. In contrast, in the absence of co-repressor the repressor is inactive and does not bind to the operator, resulting in transcription of the structural genes. This kind of control is referred to a NEGATIVE CONTROL since the function of the regulatory gene product (repressor) is to turn off transcription of the structural genes.

Enzyme induction -eg. the lac operon -
The repressor acts by binding to a specific region of the DNA called the operator which is adjacent to the structural genes being regulated. The structural genes together with the operator region and the promoter is called an OPERON. However, the binding of the repressor to the operator is prevented by the inducer and the inducer can also remove repressor that has already bound to the operator. Thus, in the presence of the inducer the repressor is inactive and does not bind to the operator, resulting in transcription of the structural genes. In contrast, in the absence of inducer the repressor is active and binds to the operator, resulting in inhibition of transcription of the structural genes. This kind of control is referred to a NEGATIVE CONTROL since the function of the regulatory gene product (repressor) is to turn off transcription of the structural genes.
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