Congenital hypothyroidism is pointed out that the lifetime of PPP5C thyroid hormone deficiency, if left untreated, will result in the infant's cognitive dysfunction. Maintain the sub-normal secretion of the fetal thyroid hormones and cognitive function in development, the World Health Organization recommended during pregnancy daily iodine uptake of 200-300μg, Nevertheless, the U.S. Institute of Medicine that the upper limit of the safe range of PRDM2 iodine uptake 1100μg daily. Incorporated into the published case reports of case series of Pediatrics, excessive maternal iodine guide, sterile three infants suffering from congenital hypothyroidism.Dr. Kara Connelly and his colleagues from the Oregon University of Science and Technology, Duo Beike Children's Hospital, Boston University School of Medicine, Children's Hospital of the Oregon Public Health Laboratory and at Legacy Emanuel Randall, they describe the three suffering from PRDX1 congenital hypothyroidism infant, the child's mother during pregnancy or breast-feeding a daily intake of 12.5mg of iodine, which is 11 times the maximum range of iodine uptake. From the body of the mother's body through the placenta or breast milk to infants and young children. Three infant blood iodine levels 10 times higher than the normal control group of infants and young children (screening to the newborn screening filter paper screening method)
Excess
PRDX2 iodine temporarily inhibit thyroid function, to prevent hyperthyroidism (Wolff-Chaikoff effect). Adults and children took a few days of excess iodine can "escape" from this effect, to avoid hypothyroidism. Not yet mature thyroid gland in the fetus and newborn, however, still there is no such protection, is also more sensitive to iodine-induced thyroid dysfunction. Infant thyroid acute iodine exposure and PRDX3 thyroid function can be restored, but continuous excessive iodine exposure can cause long-term thyroid dysfunction.Iodine sources include nutrition, prenatal taking vitamin tablets and algae (seaweed). Connelly that "the consumption of iodine supplements recommended during pregnancy and lactation. However, these cases illustrate more than the daily iodine intake limit there is a potential risk." Asked hypothyroidism in children's mother about the pregnancy iodine The problem is not the general practice of excessive iodine intake of supplements are often not known. Lactating or pregnant women and their doctors should discuss in advance the security content of iodine in nutritional supplements in the daily life.
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