The researchers found a new target for potential AIDS treatment

Recently, researchers at the University of California, San Francisco (UCSF), through the study found, in laboratory infected with simian immunodeficiency virus (SIV) macaque, because there are certain types of PTHLH immune cells in the body's intestinal, compared with other monkeys lower viral load levels in the blood, and infection six months later, monkeys can freely control the SIV. SIV is a retrovirus that can infect primates, humans infected with SIV can slowly develop for HIV infection. Can promote SIV in the macaque monkey AIDS research in animals, SIV can understand HIV and how to play a role in the PTI human body to provide new ideas. The UCSF researchers more clearly why some infected with HIV can more easily control the HIV and not subject to its harm, and can live better.The body of Th17 cells has the effect of protecting the body, they are a group against a disease found in primates and human intestinal immune cells, can effectively kill of HIV, the UCSF researchers before the study found that SIV infection can The error caused by the body's protective immune effect, which led to the protective effect of Th17 cells in the intestine to reduce, and ultimately reduce PTK2 bacteria, viruses, mucosal defense. Even more interesting is that in the study, Th17 cells does not by SIV of the invasion, such as African green monkeys infected with SIV, and will not show disease.
 
Carry more of Th17 cells in animals can be well controlled SIV, and this depends in part on the PTK2B macaques can generate more activity of SIV-specific CD4 T cells to produce more effective immunization effect against infection. The researchers next step of research is the observation of Th17 cells more effectiveness, researchers may detect Th17 cells, PTK6 interleukin-17 and cytokine release, and detect whether it has a certain effect. The researchers said that in the course of treatment can increase the number of Th17 cells, which will increase the resilience of the patient body for HIV. Relevant research results published in the May 30, the internationally renowned journal Science Translational Medicine.This study, the researchers measured the level of Th17 cells in the 16 macaques in the intestine, these macaques with SIV infection, the researchers found more Th17 cells in monkeys can better stand for SIV, in the intestine. Subsequent researchers to the high level of Th17 cells in rhesus monkeys fed drugs, the drug can be removed Th17 cells, Finally, the researchers found that lower ability to significantly reduce the control of SIV, the Th17 level macaque compared to the previous.Earlier studies only clarify the cause of viral infection and inflammatory findings, the researchers found that inflammation can be induced by an enzyme, an enzyme that can destroy the function of Th17 lose the protection effect of Th17, the disease spread rapidly. Instead, the researchers found to contain more Th17 cells in animals can reduce the risk of virus infection, post-researchers will conduct in-depth study to see if we can provide some treatment ideas and suggestions for clinical. This study was funded by the U.S. National Institutes of Health and other agencies to support.