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Home Q & A Board Biology-Related Homework Help Cell Biology
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tapey1996 tapey1996
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8 years ago
Briefly describe positive and negative selection of T cells in the thymus.
Textbook 
Clinical Laboratory Immunology

Clinical Laboratory Immunology


Edition: 1st
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#1
8 years ago
Positive selection selects for those T cells that react with MHC: self antigen. Negative selection eliminates those that react strongly with MHC: self antigen. Thus, successful T cell differentiation selects for MHC restricted TCR's with low affinity for self antigens. Cells that fall outside this range, primarily die via apoptosis. The rationale here is that a T cell that binds weakly to self MHC/self Antigen will not be activated but will be activated by a stronger binding to self MHC/ foreign Antigen complex
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