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Home Q & A Board Biology-Related Homework Help Cell Biology
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ehd123 ehd123
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8 years ago
What is meant when "T-lymphocytes are HLA restricted" in terms of recognizing antigens?
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4 Replies
B.Sc in Biology
M.Sc Neuroscience
PhD. Candidate in Neuroscience

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#1
Educator
8 years ago
Refers to the fact that a given T cell will recognize a peptide antigen only when it is bound to a host body's own MHC molecule. Normally, as T cells are stimulated only in the presence of self-MHC molecules, antigen is recognized only as peptides bound to self-MHC molecules.
ehd123 Author
wrote...
#2
Valued Member
8 years ago
Thank you Slight Smile So it is restricted in the sense that it won't target self antigens, and will recognize foreign antigens only when bound to MHC and nothing else?
B.Sc in Biology
M.Sc Neuroscience
PhD. Candidate in Neuroscience
wrote...
#3
Educator
8 years ago
Quote from: ehd123 (8 years ago)
Thank you Slight Smile So it is restricted in the sense that it won't target self antigens, and will recognize foreign antigens only when bound to MHC and nothing else?

Right
ehd123 Author
wrote...
#4
Valued Member
8 years ago
Many thanks Slight Smile
B.Sc in Biology
M.Sc Neuroscience
PhD. Candidate in Neuroscience
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