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Which of the following prevents polyspermy?

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Which of the following prevents polyspermy?

Which of the following prevents polyspermy?
A) sealing of the corona radiata and hardening of the zona pellucida
B) sealing of the corona radiata and release of toxins to sperm by the fertilized ovum
C) inactivation of sperm-binding proteins in the zona pellucida and hardening of the zona pellucida
D) release of toxins to sperm by the fertilized ovum and hardening of the zona pellucida
E) inactivation of sperm-binding proteins in the zona pellucida and release of toxins to sperm by the fertilized ovum

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