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What causes the increase in interstitial osmotic pressure that occurs during edema?

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What causes the increase in interstitial osmotic pressure that occurs during edema?

What causes the increase in interstitial osmotic pressure that occurs during edema?
A) stimulation of sensory neurons
B) leukocyte migration
C) recruitment of leukocytes
D) increased blood flow
E) increased capillary permeability

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