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Home Q & A Board Biology-Related Homework Help Cell Biology
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8 years ago
Why must insulin be injected into patients with diabetes mellitus type 1 as opposed to oral administration?
A) Insulin is such a small molecule that it easily passes through the highly vascularized tissue of the oral mucosa and enters the blood stream too quickly, causing a hypoglycemic crash.
B) Insulin is a peptide that would be degraded in the gastrointestinal tract and would therefore only be absorbed as individual amino acids.
C) Insulin is a hormone, so it must be injected directly into the bloodstream to be effective.
D) Since the absorbed contents of the GI tract first passes through the liver before moving on into the general circulation, it creates a first-pass effect which weakens its effectiveness.
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