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Home Q & A Board Biology-Related Homework Help Cell Biology
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mkzb mkzb
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7 years ago
The DNA in a human chromosome is about 10cm in length.  A typical human cell has a diameter of 15µm, and its nucleus occupies 30% of the cell volume.  What is the minimum number of times the DNA in this human chromosome must be folded to fit within the cell?
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#1
7 years ago
Chromosomal DNA is highly organized in an interphase chromosome. It is more than just a question of folding it into the available space. The DNA is wrapped around histones. The histones associate into higher-order structures. It is also now known that there are specific interactions of chromosomal locations. See this paper, for example:

https://www.researchgate.net/deref/http%3A%2F%2Fwww.nature.com%2Farticles%2Fncomms7178
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#2
7 years ago
You can measure DNA length using an atomic force microscope.

The first step of packing is realized by the winding of DNA around a protein core. Next phase  is the coiling of beads in a helical structure called the 30 nm fiber.

https://www.researchgate.net/deref/http%3A%2F%2Fwww.ndsu.edu%2Fpubweb%2F~mcclean%2Fplsc431%2Feukarychrom%2Feukaryo3.htm
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