The
neuroeffector junction describes the synapse between neurons of the autonomic nervous system and their effector organs. The anatomy of these structures is quite different from the typical neuron-neuron synapse. The
postganglionic neuron does not have a discrete, well-defined axon terminal. Rather, those neurons contain numerous swellings along their length (varicosities). Within those varicosities, neurotransmitters (
norepinephrine and
acetylcholine) are synthesized and stored in vesicles, as occurs at axon terminals. However, while the swellings contain the
voltage-gated calcium channels that are required for the release of neurotransmitter, they also contain the voltage-gated sodium and potassium channels that are required for the propagation of an action potential along the length of the axon. At the same time, the distance between a varicosity and the postsynaptic membrane is greater than what is observed in the synaptic cleft of other synapses.
In the somatic nervous system, the synapse (
neuromuscular junction) couples the motor neuron to skeletal muscle fibers. The terminal bouton of the motor neuron contains acetylcholine stored in vesicles. The motor end plate is a specialized region of the skeletal muscle that contains an invagination where nicotinic receptors are located. Surrounding this invagination are local regions of high
acetylcholinesterase concentration.