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Can high concentrations of bile salts inhibit pancreatic lipase activity?

michaelW

wrote...

Posts: 19

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12 years ago

Can high concentrations of bile salts inhibit pancreatic lipase activity?

I know that, at certain concentrations, bile salts increase the activity of lipase but i read that at concentrations which are too high; the lipase is inhibited.

Is this true?

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nursemom2013

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#1

12 years ago

Yes -but because of colipase the lipases work,see below.

Lipases are inactive on an emulsified triglyceride substrate in the presence of micellar concentrations of bile salts, such as those found in the small intestine during digestion. Bile salts are amphiphilic molecules mainly found adsorbed at the oil-water interface or dispersed as mixed micelles in solution. The bile salt coating of triglyceride globules prevents the pancreatic lipase adsorption, and thus lipolysis, at the oil-water interface. However, colipase, a specific lipase-anchoring protein present in the exocrine secretion of pancreas, counteracts this effect through the formation of a specific 1:1 complex with lipase that facilitates its adsorption at bile salt-covered lipid-water interface.

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