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tony123 tony123
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11 years ago
We hear pften about the mapping of the human genome, but how is it possible to have a definitive map when each individual human has slight variation in genetic expression? How can they therefore be certain that the map they've constructed is one of a normal human rather than containing some genetic abnormalities?
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#1
11 years ago
Regardless of mutations, every human has certain repeating sequences. The lengths of the sequences differ, but they are all present. The Human Genome Project merely identified these similarities, thus constructing the human genome. It didn't simply identify specific nitrogenous bases and use that as a map.
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#2
11 years ago
The amount of differences in our genetic makeup does not compare to the amount of similarities. A vast amount of nucleotide sequences match exactly between all individuals.
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#3
11 years ago
Good point.  No one claims that the person whose genome was mapped is typical of all humans.  It is a starting point, a reference, so that one can determine how much variation is in the different genes in the future.  Of course the reference genome may well be atypical and it may be missing some genes found in most people. We don't know if that is the case until we compare the reference genome by randomly sampling genes in other individuals.
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