A patient asks the pharmacy technician why withdrawal syndrome occurs when some drugs are stopped. ...

A patient asks the pharmacy technician why withdrawal syndrome occurs when some drugs are stopped. What is the best response by the pharmacy technician?

1.   "This is a misconception. All abused substances cause withdrawal syndrome."
2.   "Only illegal substances cause withdrawal syndrome."
3.   "A substance must be abused for at least a year to cause withdrawal syndrome."
4.   "Over time, the body's cells are tricked into believing it is normal for that substance to always be present, and when it is no longer present, the body experiences withdrawal syndrome."