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11 years ago
I am looking at DNA replication and I notice that when DNA replication occurs, the replication forks go in both directions. I understand that helicase is responsible for separating the two DNA strands, but from what I can tell it only goes in one direction. My textbook does not mention this, but are there two helicase molecules working together to separate the DNA strands in both directions? And if so, would there also be two gyrase/topoisomerase II molecules?

Thank you in advanced.
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#1
11 years ago
They work separately, unwinding the DNA in opposite direction in respect to the replication origin.  Both topoisomerase and gyrase operate to stabilize and relax the DNA while it's being replicated.  The replication process that is taught in high school biology is oversimplified, the actual pathway (the one we believe occurs) is actually very complicated.

If you are interested here is a taste of what I am talking about. http://pathwaymaps.com/maps/705/ enjoy!!
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11 years ago
I concur with algamast on this one. 
Machiavelli
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