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Explain the metabolic relationship between haemoglobin synthesis and folic acid deficiency.
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•   Folic acid is itself not biologically active until it has been converted into tetrahydrofolate via the enzyme dihydrofolate reductase in the liver. Therefore, folic acid is a precursor of tetrahydrofolate.

•   In order to biosynthesize glycine, the amino acid serine is required, where the enzyme serine hydroxymethyltransf erase catalyses the reaction between serine and tetrahydrofolate into glycine.

•   The committed step for porphyrin biosynthesis (the prosthetic group that contains an iron atom contained in the center of a large heterocyclic organic ring) is the formation of D-aminolevulinic acid by the reaction of the amino acid glycine and succinyl-CoA, from the citric acid cycle. Therefore, glycine is a precursor of porphyrin.
[1] Folic Acid Right Arrow Tetrahydrofolate
[2] Tetrahydrofolate Right Arrow Glycine
[3] Glycine Right Arrow Porphyrin

•   In all, a lack of folic acid impairs hemoglobin synthesis.
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