You need to login first

Login information

Haven't yet registered?

×
* * * *

Donate

Your donation is safe and helps support the issues and causes you care about most.
Pages: 1  Down
  New Topic  |  Print  
Explain the metabolic relationship between haemoglobin synthesis and folic acid
Read 1307 times | 1 Replies | Average Rating: Not Rated Yet
bio_man
Megalodon
*****
*
Posts: 11398
Points: 1230
Rep:  +693   -1

Joined: Aug, 2010
Flag:
Activity: 100%

Reward Me Through PayPal!WWW

Seeking a more comfortable homework help environment? Homework Clinic
Explain the metabolic relationship between haemoglobin synthesis and folic acid deficiency.

LoggedReport this PostReport Abuse


Please donate to keep this website running.

Reply# 1
*
Posts: 11398
Points: 1230
Rep:  +693   -1

Explain the metabolic relationship between haemoglobin synthesis and folic acid
Dec 25, 2010

•   Folic acid is itself not biologically active until it has been converted into tetrahydrofolate via the enzyme dihydrofolate reductase in the liver. Therefore, folic acid is a precursor of tetrahydrofolate.

•   In order to biosynthesize glycine, the amino acid serine is required, where the enzyme serine hydroxymethyltransf erase catalyses the reaction between serine and tetrahydrofolate into glycine.

•   The committed step for porphyrin biosynthesis (the prosthetic group that contains an iron atom contained in the center of a large heterocyclic organic ring) is the formation of D-aminolevulinic acid by the reaction of the amino acid glycine and succinyl-CoA, from the citric acid cycle. Therefore, glycine is a precursor of porphyrin.
[1] Folic Acid Right Arrow Tetrahydrofolate
[2] Tetrahydrofolate Right Arrow Glycine
[3] Glycine Right Arrow Porphyrin

•   In all, a lack of folic acid impairs hemoglobin synthesis.



Report this PostReport Abuse
Pages: 1    Up
  New Topic  |  Print  
 
Related Topics
Replies Author Last post
1
Reply
What is the metabolic relationship between haemoglobin synthesis and folic acid in Biochemistry
Started by biolove | Views: 2442
Last post Last post by bio_man
Nov 17, 2010
3
Replies
During development a lack of folic acid can result in? in Anatomy and Physiology
Started by Octavio113 | Views: 224
Last post Last post by dauterjudy938
Jan 28, 2013
0
Replies
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are metabolic derivat in Nutrition and Food Sciences
Started by mikael | Views: 40
Last post Last post by mikael
Oct 31, 2013
1
Reply
What is the mechanism of action of folic acid? in Biochemistry
Started by leebond | Views: 129
Last post Last post by Alexx
Jan 18, 2014
Note: This topic is currently locked from adding new posts. Only administrators and moderators can reply. If you'd like to contribute to this topic, start a new thread and make reference to this one. Otherwise, contact a moderator for more options.