Section 5 - (PT1) Pharmacokinetics

Click to edit Master title style Click to edit Master text styles Second level Third level Fourth level Fifth level Click to edit Master title style Click to edit Master text styles Second level Third level Fourth level Fifth level Principles of Pharmacology and Toxicology (BIOL3020) Drugs must move across cell membranes Which passage routes are important for drugs q  Lipid Mediated Transport Transport though cells varies among drugs  How does this affect distribution 2 2 An example of pH partition AH A- BH Gastric Juice Urine Consequences of pH partition AH A- AH AH Carrier Mediated Transport  P-glycoprotein  Plasma proteins influence the activity of drugs P  Plasma proteins also influence absorption and elimination of drugs Extensive plasma protein binding slows drug elimination (ie, metabolism and/or excretion through kidneys) Partition into body fat and other tissues  The blood brain barrier j  Peripheral Capillary Drug Absorption  Routes of administration Oral Administration 2 2 Other factors affecting gastrointestinal absorption 0  Other Forms of Administration Cutaneous administration (Skin) Lipid soluble drugs Nicotine Patch Estrogen patch Nasal sprays Eye drops Drugs used to treat glaucoma Administration by inhalation Bronchodilators  How is distribution measured Examples of distribution Insulin has a low Vd (retained highly in plasma) Morphine has a high Vd (accumulates in fat tissue)