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SlideshowReport

Defective differentiation and leukemia

Description
Different types of blood cells develop from a multipotential (pluripotent) stem cell in the bone marrow. The precursors of differentiated cells undergo several rounds of cell division as they mature, but cell division ceases at the terminal stages of differentiation. The differentiation of leukemic cells is blocked at early stages of maturation, consistent with their continued proliferation.
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