Reciprocal translocation in chronic myelogenous leukemia

Reciprocal translocation in chronic myelogenous leukemia. Reciprocal translocation between chromosomes 9 and 22 [t(9;22)] moves the c-ABL gene from chromosome 9 into the BCR gene region on chromosome 22, forming a c-ABL–BCR fusion gene on the shortened copy, called the Philadelphia chromosome, of chromosome 22. The chimeric c-ABL–BCR protein produces CMLReciprocal translocation in chronic myelogenous leukemia. Reciprocal translocation between chromosomes 9 and 22 [t(9;22)] moves the c-ABL gene from chromosome 9 into the BCR gene region on chromosome 22, forming a c-ABL–BCR fusion gene on the shortened copy, called the Philadelphia chromosome, of chromosome 22. The chimeric c-ABL–BCR protein produces CML

Reciprocal translocation between chromosomes BCR 9 and 22 —> Centromere 5<BCR + C-ABL Philadelphia 22 chromosome C-ABL 9 Normal “9:22) chromosomes Translocation chromosomes t(9;22)