Example of reciprocal translocation in Burkitt’s lymphoma

Example of reciprocal translocation in Burkitt’s lymphoma. Translocation of the c-MYC gene from chromosome 8 that has lost a portion of its long arm (8q–) to the IgV immunoglobulin gene region on chromosome 14 that has gained a portion from chromosome 8 containing c-MYC (14q+). The translocation overproduces c-MYC protein to cause Burkitt’s lymphomaExample of reciprocal translocation in Burkitt’s lymphoma. Translocation of the c-MYC gene from chromosome 8 that has lost a portion of its long arm (8q–) to the IgV immunoglobulin gene region on chromosome 14 that has gained a portion from chromosome 8 containing c-MYC (14q+). The translocation overproduces c-MYC protein to cause Burkitt’s lymphoma

Centromere Reciprocal translocation of chromosomes 8 and 14 —> + c-MYC l9V 8 14 8q— 814q+ Normal Translocation chromosomes rhrnmncnmnc