The functional role of pRB. The pRB protein product of RB1

The functional role of pRB. The pRB protein product of RB1 joins with transcription factor E2F and then with the cyclin–CDK complex. When E2F is released from the complex, the E2F binds to DNA and drives the transcription of genes whose expression is required for cell cycle progression. The absence of pRB leads to cell division that is not turned off at the right time in retinal cells and certain other cellsThe functional role of pRB. The pRB protein product of RB1 joins with transcription factor E2F and then with the cyclin–CDK complex. When E2F is released from the complex, the E2F binds to DNA and drives the transcription of genes whose expression is required for cell cycle progression. The absence of pRB leads to cell division that is not turned off at the right time in retinal cells and certain other cells

o In normal cells, pRB binds transcription activator pro- tein E2F. 9 A cyclin—CDK complex binds pRB—E2F. and a biochemical process can release E2F. 0 ...it binds to DNA and acti- vates transcription of several genes, producing proteins 9 When E2F is required in S phase. released... —-> l Transcription mRNA /\/V\/\/\/ l Translation Cell cvcle protein