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SlideshowReport

Formation of a blood clot

Description
a. Red blood cells enmeshed in the insoluble strands of a fibrin clot.

b. Electron micrograph of part of a fibrin fiber.

c. Schematic view of how fibrin monomers are thought to associate to form a fiber. Removal of fibrinopeptides A and B from fibrinogen by thrombin makes sites accessible for association with complementary sites a and b on adjacent monomers. The molecules are believed to overlap as shown because the striations seen in the fibers are 23 nm wide, exactly half the length of the fibrinogen molecule.
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