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SlideshowReport

Regulation of fatty acid synthesis in animal cells

Description
The rate-limiting enzyme, acetyl-CoA carboxylase (ACC), is controlled by both allosteric (citrate and long-chain fatty acids) and covalent modification mechanisms.

Phosphorylation by AMP-activated protein kinase (AMPK) or cyclic AMP–dependent protein kinase (PKA) inactivates ACC.

Insulin stimulates fatty acid synthesis by increasing glucose uptake and increasing flux through pyruvate dehydrogenase to produce acetyl-CoA.

The dephosphorylated form of PDH is the enzymatically active form.
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