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Nonsteroidal anti-inflammatory drugs (NSAIDs)

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Ibuprofen and naproxen are examples of nonselective COX Inhibitors.

Rofecoxib (Vioxx®) and celecoxib (Celebrex®) are selective COX-2 inhibitors.

The phenylsulphonamide moieties, which contribute to their selectivity, are highlighted in red.
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