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Porphyrin biosynthesis
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Description
1. Formation of a pyrrole ring.
2. Condensation of four pyrrole moieties, giving a cyclic tetrapyrrole.
3. Side chain modifications and ring oxidations.

Porphyrias involve abnormal accumulations of heme precursors, either from overproduction of the unnatural type I porphyrins or from abnormally high flux through d-ALA synthetase.
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