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Model of the purinosome

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The figure shows a hypothetical model for a multi-enzyme complex in animal cells that transforms PRPP to IMP.

Serine hydroxymethyltransferase (SHMT) and the trifunctional enzyme C1-tetrahydrofolate (THF) synthase, also proposed to be part of the complex, channel one-carbon units from serine into 10-formyl-THF for the transformylase reactions.
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