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SlideshowReport

O6-alkylguanine alkyltransferase

Description
Thus, alkylation of a DNA-guanine stimulates a GC  AT transition.

Repair of this type of damage involves an unusual enzyme, O6-alkylguanine alkyltransferase, which transfers a methyl or ethyl group from an O6–methylguanine or O6-ethylguanine residue to a cysteine residue in the active site of the protein.

Having become alkylated, it cannot remove the alkyl group, and the protein molecule turns over.
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