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Ex vivo and in vivo gene therapy for a patient with a liver disorder

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Description
Ex vivo gene therapy In vivo gene therapy
| | |
Normal gene
Remove small (51" C; 22’,“ for a blood
portion of liver ’m
to isolate cells *
clotting protein
Viruses as
vectors for
gene delivery
Directly introduce
normal gene for
clotting protein into
liver cells in patient
Introduce Ogre Transplant liver
normal 6 N‘" cells back into patient. Patient with liver cell
genes for M“ —> Genetically altered genetic defect, lacks gene
clotting 0 ”us provide for blood clotting protein
protein . clotting protein
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