Haplotype inheritance

(a) Syntenic alleles for two SNPs (A and B) and a disease gene (D) that form a haplotype. (b) Haplotype inheritance in a family is used to identify recombinant and nonrecombinant chromosomes. (c) Recombination between the homologs of II-5 produces two recombinant chromosomes that are identified by haplotype changes(a) Syntenic alleles for two SNPs (A and B) and a disease gene (D) that form a haplotype. (b) Haplotype inheritance in a family is used to identify recombinant and nonrecombinant chromosomes. (c) Recombination between the homologs of II-5 produces two recombinant chromosomes that are identified by haplotype changes

(a) 1 1 2 1 —+—4—4— —+—+—4— —|—|—I— —i—I—|— 32 A2 0’ 8, A2 0’ (b) | II III (C) 32 A, d 32 A, D Parental homologs Recombinant homologs in ”-5 in III-5 (B1A1d) and III-6 (3,4,0)