|
Description
TABLE 19.1 Some Prom-oncogenes and Tumor-Suppressor Genes
Prom-oncogene
Crmyc
c-kit
RARa
E6
Cyclins
Tu mar-Suppressor
RB1
APC
p53
BRCA 7, BRCAZ
Normal Function
Transcription factor, regulates cell
cycle, differentiation, apoptosis
Tyrosine kinase, signal transduction
Hormone-dependent transcription
factor, differentiation
Human papillomavirus encoded
oncogene, inactivates p53
Bind to CDKs, regulate cell cycle
Normal Function
Cell-cycle checkpoints, binds E2F
Cellrcell interaction
Transcription regulation
DNA repair
Alteration in Cancer
Translocation, amplification,
point mutations
Mutation
Chromosomal translocations with
PML gene, fusion product
HPV infection
Gene amplification, overexpression
Alteration in Cancer
Mutation, deletion, inactivation by
viral oncogene products
Mutation
Mutation, deletion, viruses
Point mutations
Associated Cancers
Lymphomas, leukemias, lung
cancer, many types
Sarcomas
Acute promyelocytic leukemia
Cervical cancer
Lung, esophagus, many types
Associated Cancers
Retinoblastoma, osteosarcoma,
many types
Colorectal cancers, brain, thyroid
Many types
Breast, ovarian, prostate cancers
Related Images
|
