Hierarchical clusters in a microarray experiment using RNA samples from Saccharomyces cerevisiae

a) Hierarchical clusters in a microarray experiment using RNA samples from Saccharomyces cerevisiae grown for varying times in culture (experiments 1–15). (b) High (red), intermediate (black), and low (green) levels of gene expression for Drosophila genes that exhibit a circadian rhythm.

(b) (a) .'$; - i =7 :1 F 3 Experiments 1—15 f'" ‘ 5.5-? r5. '_ Genes "7::- i: ATL‘Wfi: unknown -u-Em- :2 '3' if SCW11 cell wall biogenesis glucanase (putative) CLBG cell cycle B-type cyclin; S phase K004 bud growth protein kinase McD1 mitosis, isler chromatid cohesion x POLao DNA replication DNA polymerase processivity lactor = unknown .-’::.. : RFA1 DNA replication replication factor A, 69 kD subunit 1" :- unknown ‘I. :2" STPS tRNA splicing L. i] " Ill 1-" T056 unknown; similar to Mid2p ISFl1 slaurosporine resistance protein kinase 3H04 bud site selection. plasma membrane protein CSI2 cell wall biogenesis chitin synthase 3 subunit SVSI vanadate resistance CLN2 cell cycle G1IS cyclin 1 in “‘ 15‘“ ha; I It I i I. l I? I. in ‘4“; H Cluster of down- Cluster of up- regulated genes regulated genes