Cross-regulatory interactions among gap genes

(a) Thepaiemlegeneeven—skbped(eve)anditsenimmodds /Adjacent genes ADAM E VEN-SKIPPED (EVE) APPLE I mRNA - - DNAW -7.4 -S.S -3.9 -1.1 +1.5 +3.2+4.8 +6.6 +8.4 kb eve enhancer __ modules (8) I (7) "' .. (stripe number) (3) [(2% StripeZenhanoer module * . eve activators: ‘ Parasegment 1 2 3 4 S 6 (c) Oocupancyofregulatorysifioneve sbipelenhanoermodde incifferentparasegments In parasegment 3 (eve stripe 2) in parasegment 3, the concentration of the activators Bicoid and Hunchback is high, while the concentration of represses Kn'ippel and Giant is causing aaivabmoietehsuipez. InparasegmentsZandd,eve isnotactivatedbecauserepresso rsites areoccupiedbyGiantandKrfippel. Giant o .0-"" In parasegment 2 (no eve activation) . Bicoid In parasegment 4 (no eve activation) Hunchback