Human mitochondrial transcription

HSP2 (full-length transcript) ' Only three HSP1 (only rRNA transcribed) Pr0m0t0r5<HSP1 & 2, and LSP), two for the ” heavy" strand and one for the ”light” strand, T drive transcription in human mitochondria. \ l i l l l l l \ l l i F D-loop 'U A i Term L LSP (full-length ND 7 transcript) Genes encoded on the light strand (inside of the circle). Genes encoded ND5 on the heavy strand (outside of the circle). mtDNA M : Q Homo sapiens I 16.569 bp Genes encoding rRNA Protein-coding genes (blue) and mRNAs (red) CO] 5 are primarily on the are flanked by tRNA / heavy transcript; genes. The three tran- D WRNDB, ND4L tRNAs are equally scripts are cleaved, COIIK 8 6 C O / I distributed (thick black releasing the tRNAs, ATPase lines)_on both heavy rRNAs, and mRNAs. and light transcripts.