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Modularity of protein domains

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EPC-like protein, a protein type found in all eukaryotes, is used as an example. (a) Proteins are often modular, composed of discrete domains (e.g., Ep1, Ep2, PHD, Br, BMB, Znf). Complex proteins can evolve by mixing and matching of protein domains, usually through a process known as exon shuffling. (b) Multicellular eukaryotes have more complex protein architectures than single-celled eukaryotes
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