Mutagenicity of aflatoxin B1 determined by the Ames test

Aflatoxin B1 induces a high rate of reversions in his− bacteria with base-pair substitution mutations (strain TA 100), but not in frameshift mutants (strain TA 1538)Aflatoxin B1 induces a high rate of reversions in his− bacteria with base-pair substitution mutations (strain TA 100), but not in frameshift mutants (strain TA 1538)

2000 TA 100 1500 hi5' S. typhimurium strain with base— pair substitutions 1000 Revertant colonies/plate 500 Mr S. typhimurium strain with frameshift mutations TA 1538 / / 20 40 60 80 100 120 140 Aflatoxin B1 dose (ng)