Cis-element regulatory structures in eukaryotes

(a) Typical cis-regulatory structure of a Saccharomyces cerevisiae gene. (b) Typical cis-regulatory structure of a gene of a multicellular eukaryote(a) Typical cis-regulatory structure of a Saccharomyces cerevisiae gene. (b) Typical cis-regulatory structure of a gene of a multicellular eukaryote

(a) Saccharomyces cerevisiae Cis-regulatory structure Cis elements consist of single binding / sites and are located close to and generally 5' of the gene. Upstream Gene of interest gene 500 bp Cis elements are complex, with multiple binding sites, and can be located at a distance from the gene, either upstream, intronic, or, occasionally, exonic. ~ \ .._.. w P ‘ xx m u \ I r \\ w“ (b) Multicellular eukaryote cis-regulatory structure Upstream H Gene of interest Downstream gene gene l = Transcription start sites » = exons — = position of core promoter regions