Eukaryotic enhancer and silencer module

(a) Modules consist of multiple binding sites for both activators and repressors, with the output from the module resulting through integration of the effects of all the bound factors. (b) Pioneer factors bind first, allowing the binding of additional transcription factors(a) Modules consist of multiple binding sites for both activators and repressors, with the output from the module resulting through integration of the effects of all the bound factors. (b) Pioneer factors bind first, allowing the binding of additional transcription factors

(a) Activators: Repressors: Pioneer factor binds first: 9 Facilitating binding of other factors: W (b)