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Home Q & A Board Biology-Related Homework Help Cell Biology
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convivium convivium
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10 years ago Edited: 10 years ago, convivium
Could someone explain how angiogenic inhibitors work?

I saw this explanation but I am looking for a bit more detail. 

Also, if you know of any medical breakthroughs in angiogenesis inhibitors please list them.

I am just trying to get a firm grasp on this process.

Thank you.
Post Merge: 10 years ago

sorry here is the post

https://biology-forums.com/index.php?topic=12652.0
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#1
Staff Member
Educator
10 years ago
It is a chemical that interferes with the signals to form new blood vessels. In other words, they work by blocking the cascade of events that cause blood vessels to form.

Different drugs work differently, so look up:

Bevacizumab (Avastin®)

Cetuximab (Erbitux®)

Sorafenib (Nexavar®)

Sunitinib (Sutent®)

Thalidomide (THALOMID®)
Mastering in Nutritional Biology
Tralalalala Slight Smile
convivium Author
wrote...
#2
10 years ago
Thanks for the reply.

Do happen  to know which part of the cascade is interrupted?

 
wrote...
#3
Staff Member
Educator
10 years ago Edited: 10 years ago, padre
HI again


Cancer cells can stimulate angiogenesis, thereby facilitating their own growth. A key component of the intracellular signaling pathways is mTOR, which is involved in growth of both the cancer and the vascular cells.

Not sure if this relates to it exactly, but check out the link, which describes what's going on in the image.
Source  http://www.d.umn.edu/~jfitzake/Lectures/DMED/Antineoplastics/AngiogenesisInhibitors/VEGF&mTOR.html
Mastering in Nutritional Biology
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