Antibiotic Inhibitors of Protein Synthesis

Table 9.9 Antibiotic Inhibitors of Protein Synthesis Antibiotic Chloramphenicol Eryth romycin Streptomycin Tetracycline licyéiia’h'éki’réia‘é ' Pu romycin Inhibitory Action Blocks polypeptide formation by inhibiting peptidyl transferase in the 708 ribosome (antibacterial action) Blocks translation by binding to 50$ subunit and inhibiting polypeptide release (antibacterial action) inhibits translation initiation and causes misreading of mRNA by binding to the 305 subunit (antibacterial action) Binds to the 305 subunit and inhibits binding of charged tRNAs (antibacterial action) ‘ Blocks p3i9ggggi‘ag‘mgaaat;“ inhibiting peptidyl transferase activity in ME?€_§9§_fll39§9fl73(60???”lff‘IX9E‘E‘75‘EFl9P?,, Causes premature termination of translation by acting as an analog of charged tRNA (antibacterial and antieukaryote action)