Match the type of phenotypic change below with the type of genetic change most likely to cause it. ...

Match the type of phenotypic change below with the type of genetic change most likely to cause it. Each type of genetic change may be used more than once, or may not be used at all.
 
  Phenotypic changes:
  1.
 
  A protein normally localized in the nucleus is now localized in the cytoplasm. _________
  2. A protein acquires a DNA-binding domain. _________
  3. Tandem copies of a gene are found in the genome. _________
  4. A copy of a bacterial gene is now found integrated on a human chromosome. _________
  5. A protein becomes much more unstable. _________
  6. A protein normally expressed only in the liver is now expressed in blood cells. ________
 
  Types of genetic change:
  A. mutation within a gene
  B. gene duplication
  C. mutation in a regulatory region
  D. exon shuffling
  E. horizontal gene transfer