Match the type of phenotypic change below with genetic change that causes it.

1. A protein normally localized in the nucleus is now localized in the cytoplasm.
2. A protein acquires a DNA binding domain.
3. Tandem copies of a gene are found in the genome.
4. A copy of a bacterial gene is now found integrated on a human chromosome.
5.  A protein becomes much more unstable.
6. A protein normally expressed only in the liver is now expressed in blood cells.

Types of genetic change:
A.   mutation within a gene
B.   gene duplication
C.   mutation in a regulatory region
D.   exon shuffling
E.   horizontal gene transfer