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Home Q & A Board Biology-Related Homework Help Genetics and Developmental Biology
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Salmams Salmams
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6 years ago
Fine structure genetic maps of the human genome are now constructed using either restriction fragment length polymorphisms (RFLPs) which are found about 1/6000 bp
 
  or single nucleotide polymorphisms (SNPs) which are found about 1/1330 bp. Would you expect RFLPs or SNPs to be located only in the coding regions of genes or in noncoding and repetitive sequences as well?
  What will be an ideal response?
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6 years ago
Ans: The power of using both RFLPs and SNPs for genetic maps is they are found independently of gene function and can be located anywhere in the genome. Therefore, they are found far more frequently than the number of identified genetic variants that change phenotype, allowing for far more detailed maps to be constructed. The older maps made using recombination frequencies between loci often had huge gaps where there were no variants or no variants that resulted in observable phenotypic changes.
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