The ΔG˚′ = -21 kJ/mol for the reaction catalyzed by isocitrate dehydrogenase yet the ΔG˚′ = ...

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The ΔG˚′ = -21 kJ/mol for the reaction catalyzed by isocitrate dehydrogenase yet the ΔG˚′ = ...

The ΔG˚′ = -21 kJ/mol for the reaction catalyzed by isocitrate dehydrogenase yet the ΔG˚′ = +29.7 kJ/mol for the reaction catalyzed by malate dehydrogenase. Both of these reactions involve the oxidation of a secondary alcohol. Give an explanation as to why the oxidation of isocitrate is so exergonic.

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Biochemistry

Edition: 6^th

Authors: Tymoczko, Berg

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