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bdiddydog bdiddydog
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6 years ago
Polylysine is a random coil when the pH is less than 11, while it forms an -helix if the pH is raised to greater than 12. This is because at pH 12:
 
  a. the lysine residues are negatively charged which electrostatically stabilizes the helix.
  b. the positive charges on the lysine residues stabilizes the -helix.
  c. the lysine residues are neutral which eliminates electrostatic repulsion between the R groups.
  d. the high concentration of OH ions in solution reduces the electrostatic repulsion between the R-groups.
  e. the lysine side chain changes configuration with pH.
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jacobhollyyjacobhollyy
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6 years ago
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