Disscuss the Steps of Beta Oxidation

a. Location: synthesis is in the cytoplasm, degradation in the motochondia and peroxisome
b. Carrier : in synthesis they are attached to an acyl carrier Protein, in degradation they are attached to a CoA
c. carriers: Electron NADPH in synthesis, in degradation, NAD+ and FAD

Thanks!

More differences: degradation starting material - fatty acids producing Acetyl CoA; synthesis - starts with malonyl CoA to produce fatty acids

Discuss: beta oxidation is a four-enzyme process to oxidize the beta carbon of a fatty acid to produce energy and Acetyl CoA to feed into the citric acid cycle. The initial oxidation is on alkane carbons, the only possible oxidation there is a dehydrogenation to an alkene - think succinate dehydrogenase. It requres FAD to accept the electrons. The double bond is then hydrated - water is added to create an OH group on the beta carbon. A simple NAD+ based oxidation from alcohol to ketone creates a beta-dicarbonyl compound. Finally, thiolase cleaves off a 2 carbon fragment, yielding a fatty acyl-CoA that has 2 fewer carbons and a molecule of Acetyl-CoA for further catabolism.