Why is NH4+ toxic in higher animals?

nite_n_day

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13 years ago

This is for my fourth year biochemistry course...

Why is NH4+ toxic in higher animals?

Hope you can give me some insight Frowning Face

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Would you know my name, if I saw you in heaven?

Eric Clapton

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bio_man

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13 years ago Edited: 13 years ago, bio_man

This is because it deamination in higher animals takes place solely in the liver. Therefore, ammonium can quickly accumulate and inhibit rate limiting enzymes including the enzyme glutamate dehydrogenase.

Bio_man 8)

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nite_n_day Author

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13 years ago

You surely deserve a donation for you hard work Bio_man!

I will be donating soon

THX SO MUCH!

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Would you know my name, if I saw you in heaven?

Eric Clapton

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